Indy king Joseph Gordon-Levitt (“500 Days of Summer”) has replaced James McAvoy on the untitled cancer comedy being directed by Jonathan Levine for Summit, says MTV.

The flick, now shooting in Vancouver, lost McAvoy “due to unrelated circumstances beyond his control” the studio said.

MTV ran a statement from co-star Rogen : “It’s incredibly unfortunate that circumstances outside of everyone’s control have taken James away from the project, but, with James’s blessing, we were able to have Joseph step in to take on the [lead] role of Adam. We all look forward to working with James in the future.”

The pic, also starring Anna Kendrick, Bryce Dallas Howard, Anjelica Huston and Philip Baker Hall, is an autobiographical tale by Will Eisner about a man dealing with Cancer.